Nonfatal graft-versus-host disease occurring after transfusion with leukocytes and platelets obtained from normal donors
Year: 1979
Type: article
Study design: Case Report
Abstract: There have been two previous reports of fatal graft-versus-host (GVH) disease following transfusion of leukocytes from normal donors for the supportive care of leukemic patients. We have reported a nonfatal case of GVH disease in a child with acute monoblastic leukemia who received leukocyte and platelet transfusions from normal donors. The dose of lymphocytes contained in both leukocyte and platelet concentrates obtained with a semicontinuous-flow cell separator is sufficient to cause GVH disease. Irradiation of all blood products administered to severely immunocompromised and myelosuppressed patients should be considered.
Source: Blood
Authors: D Cohen, H Weinstein, M Mihm, R Yankee
Institutions: Dana-Farber Cancer Institute, Harvard University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2410017455