Work

Discriminatory Dissolution Method Development and Validation of Etoricoxib Tablets

Year: 2016

Type: article

Abstract: The availability of a discriminatory dissolution method for use in either quality control testing or product evaluation in quality by design trials is mandatory for products intended for the developed market.This study demonstrates the systematic development of a discriminatory dissolution method for etoricoxib, a BCS Class 2 drug exhibiting highly pHdependent solubility.The pH, speed, and apparatus were simultaneously optimized and tested for method variability, reproducibility, and robustness.The discriminative power of the developed method was suitably demonstrated.

Source: Dissolution Technologies

DOI: 10.14227/dt230216p30

Authors: Yasvanth Ashokraj, Atul Daroi, Raja Gupta, Aruna Khanolkar, Amol Kulkarni, Swat Laud, Milind Pokale, Sanjeet Shedge, Praveen Date

Institution: Cipla (India)

Language: English

Topic: Analytical Methods in Pharmaceuticals

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W2413552575

FWCI: 1.223

Cites: 8

Cited by: 21

Related to: 10