Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA
Year: 2016
Type: article
Abstract: The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences (ribozymes) are known to catalyse specific biochemical reactions with remarkable efficiencies, RNA-based catalysts involving a catalytically active metal complex interacting in a non-covalent fashion with short sequences have never been evaluated to date. We report here our results, which have led to the first example involving a short RNA-based catalyst.
Source: Chemical Communications
DOI: 10.1039/c6cc03540j
Institutions: Centre National de la Recherche Scientifique, ParisTech, Université Paris Sciences et Lettres, Laboratoire de Chimie Organique, Chimie Biologie Innovation, ESPCI Paris, Noxxon Pharma (Germany), École Nationale Supérieure de Chimie de Montpellier, Université de Montpellier, Institut des Biomolécules Max Mousseron
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funder: Agence Nationale de la Recherche
OpenAlex ID: W2419259432