One-pot Multi-component Synthesis of Some Pharmacologically Significant 2,4,5-Tri and 1,2,4,5-Tetrasubstituted Imidazoles: A Review
Year: 2016
Type: article
Abstract: Heterocyclic compounds are acquiring more importance in recent years because of their pharmacological activities. Compounds containing imidazole moiety have many pharmacological properties and play important role in biochemical processes. Imidazole is a natural compound which exists in many important natural molecules such as the amino acid histidine, vitamin B12, histamine, biotin and purines like adenine and guanine. Imidazole derivatives play significant roles in various pharmacological activities such as anticancer, antibacterial, antifungal, antiviral, anti-HIV and antitubercular. This article aims to review the work in the methods of synthesis using various catalytic system, solvent condition and pharmacological potential of 2,4,5-tri and 1,2,4,5-tetrasubstituted imidazoles reported during last 15 years.
Institution: Jiwaji University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2436617320