Year: 2012
Type: article
Abstract: Background: Anxiety is an unpleasant state of inner turmoil often accompanied by cognitive, somatic, emotional, and behavioral components.There is some evidence in traditional medicine for the effectiveness of Urtica urens in the treatment of anxiety in humans.The present study was designed to study anxiolytic property of aqueous extracts of Urtica urens; an important and commonly used for its medicinal properties belongs to urticaceae family.Methods: The anxiolytic activity was evaluated with the adult mice by hole board test, and the light-dark box test, and motor coordination with the rota rod test.The efficacy of the plant extract (100-400 mg/kg) was compared with the standard anxiolytic drug diazepam (1 mg/kg i.p.). Results:The extract increased the time spent in the brightly-lit chamber of the light/dark box, as well as in the number of times the animal crossed from one compartment to the other.Performance on the rota rod was unaffected.In the hole board test, the extract significantly increased both head-dip counts and head-dip duration.Urtica urens, in contrast to diazepam, had no effect on locomotion.Conclusions: These results provides support for anxiolytic activity of Urtica urens, in line with its medicinal traditional use, and may also suggest a better side-effect profile of Urtica urens relative to diazepam.
Authors: Doukkali Z, Taghzouti K, Bouidida El H, Kamal R, El Jemeli M, Bahia B, Zellou A, Cherrah Y, Alaoui K
Institutions: Mohammed V University, Ministère de la Santé
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2436733732