Work

Characterization of Micro RNA Signature in Peripheral Blood of Schizophrenia Patients using µParafloTM miRNA Microarray Assay

Year: 2016

Type: article

Abstract: Development of biomarkers for psychiatric disease still remains challenging. Recently, numerous alterations in the expression of microRNAs (miRNAs) in peripheral blood, serum and post-mortem brain tissue have been linked to schizophrenia. Additionally, it is known that miRNAs can inactivate a target mRNA sequence through binding to its 3’UTR region. Thus, miRNAs might not only serve as prognostic biomarkers for diagnosis or prognosis of pathological conditions like schizophrenia, but could also actively modulate gene function. Therefore, the aim of this study was to test whether specific miRNA display differential expression in patients with schizophrenia vs. healthy controls by using miRNA microarray assay. Venous blood samples of 33 affected patients and 25 healthy controls were collected and the quantification of microRNAs was established using miRNA microarray assay. Moreover, we searched for potential validated target genes for each of the differentially expressed miRNAs that might play a role in the regulation of schizophrenia susceptibility genes.

Source: International Journal of Current Microbiology and Applied Sciences

DOI: 10.20546/ijcmas.2016.507.055

Authors: Tihomir I. Vachev, Nikolay T. Popov, Danail Marchev, Hristo Ivanov, Vili K. Stoyanova

Institutions: Plovdiv University, Medical University Plovdiv

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2467208895