Work

Brain activation differences in schizophrenia during context-dependent processing of saccade tasks

Year: 2016

Type: article

Abstract: BACKGROUND: Brain function in schizophrenia has been probed using saccade paradigms and functional magnetic resonance imaging, but little information exists about how changing task context impacts saccade related brain activation and behavioral performance. We recruited schizophrenia and comparison subjects to perform saccade tasks in differing contexts: (1) two single task runs (anti- or pro-saccades alternating with fixation) and (2) one dual task run (antisaccades alternating with prosaccades). RESULTS: Context-dependent differences in saccade circuitry were evaluated using ROI analyses. Distinction between anti- and pro-saccade activation across contexts (single versus dual task) suggests that the schizophrenia group did not respond to context in the same way as the comparison group. CONCLUSIONS: Further investigation of context processing effects on brain activation and saccade performance measures informs models of cognitive deficits in the disorder and enhances understanding of antisaccades as a potential endophenotype for schizophrenia.

Source: Behavioral and Brain Functions

DOI: 10.1186/s12993-016-0103-2

Authors: A. L. Rodrigue, B. P. Austin, K. A. Dyckman, J. E. McDowell

Institutions: University of Georgia, University of Wisconsin–Madison

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190