Work

1096Impact of Universal Pneumococal Vaccination in Children in Argentina

Year: 2014

Type: conference-abstract

Abstract: Background. Universal pneumococcal vaccination (UPV) in Argentina began in January 2012 using a 2 + 1 schedule using PCV13; vaccine coverage rate reached 50% in 2012, 75% in 2013. The objective was to evaluate the PCV13 impact 2 years after implementation. Methods. Multicenter (5 hospitals), prospective study. Hospitalized children (CH) < 60 months with confirmed Invasive Pneumococal Disease (IPD) and/or consolidated pneumonia (CP) (WHO criteria) during 5 years (prevaccine period: 2009-2011 and post-vaccine period: 2012-2013) were included. Patients (pts) with CP or empyema (E) confirmed by any other agent than S.pneumoniae were excluded. Demographic and clinical data were recorded. Results. Pts included 1528; 1194(78%) CP, of 51/1120(4,5%) defined as Pneumococal-CP (P-CP); E:249(16.3%), 84/234(35.9%) of them confirmed as Pneumococal-E (PE) by culture; Meningitis 38(2,5%); other IPD:51(3,3%), including bacteremia, peritonitis, arthritis. The coverage rate in 2012 was 50% and 75% in 2013. The decrease of IPD, CP and Pneumococcal Pulmonary Disease (PPD) (defined as P-CP + PE), after vaccination was: * Rate/10,000 admissions The number of admission decreased 738 (-65.1%) and admission to ICU also was reduced 45(-38.8%); in addition the decrease of number of invasive procedures avoided was: central line 30 (-37%), thoracoscopy: 20 (-83%), pleural drainage 82(-59.4%), pleural decortication 22(-48.9%); the average days of antibiotic use was reduced in 1154 (-55.08%) after vaccination program implementation 2. Hospitalizations by IPD and/or CP decreased 65.1% and requirement of ICU 38.8% after 2 years of UPV using PCV13 in our setting. Conclusion. A rapid and statistically significant decrease of IPD, CP and PPD was observed after 2 years of UVP in Argentina with a non-high coverage rate. Disclosures. All authors: No reported disclosures.

Source: Open Forum Infectious Diseases

DOI: 10.1093/ofid/ofu052.804