Electrocardiographic Parameters and Fatal Arrhythmic Events in Patients With Brugada Syndrome Combination of Depolarization and Repolarization Abnormalities
Year: 2014
Type: dissertation
Study design: Observational Study
Abstract: Objectives:This study aimed to determine the usefulness of the combination of severalelectrocardiographic (ECG) markerson risk assessment of ventricular fibrillation (VF) in patients withBrugadasyndrome (BrS).Background:Detection of high/low-risk BrSpatientsusing a noninvasive method is animportant issuein the clinical setting.Several ECG markers related to depolarization and repolarization abnormalities have been reported, butthe relationship and usefulness of these parametersin VF events are unclear.Methods:Baseline characteristics of 246 consecutive patients (236 males; mean age, 47.6±13.6 years) with Brugada type ECG, including 13 patients witha history of VF and 40 patients with ahistory of syncopalepisodes,were retrospectively analyzed.During the mean follow-up period of 45.1 months, VFin 23 patients and sudden cardiac death(SCD) in one patientwere observed.Clinical/geneticand electrocardiographic parameterswere compared with VF/SCD events.Results:Byunivariate analysis, history of VF, history of syncopal episodes, paroxysmal atrial fibrillation , spontaneous type1 pattern in the precordial leads, ECG markers of depolarization abnormalities(PQ >200ms, QRS duration ≥120ms,and fragmented QRS [f-QRS]),and those of repolarizationabnormalities(infero-lateral early repolarization [ER] pattern and QT prolongation)were associated with later cardiac events.By multivariable analysis,history of VF, history of syncopal episodes, infero-lateral ER pattern,f-QRS wereindependent predictors of documented VF and SCD (odds ratio, 19.61, 28.57, 2.87, and 5.21, respectively, P<0.05).Kaplan-Meier curves showed thatthe presence/absence ofinfero-lateral ER and f-QRS provided a worse/better prognosis (log-rank test, P<0.01). Conclusions:The combination of depolarization and repolarization abnormalitiesinBrSis associated with later VF events.The combination of these abnormalities is useful for detecting high-and low-riskBrSpatients.
DOI: 10.18926/52969
Author: 浩二 時岡
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2487705015