Year: 2016
Type: article
Abstract: Previous reports have suggested that some probiotics inhibit tumorigenesis and cancer progression. However, the molecules involved have not yet been identified. Here, we show that the culture supernatant of Lactobacillus casei ATCC334 has a strong tumour-suppressive effect on colon cancer cells. Using mass spectrometry, we identify ferrichrome as a tumour-suppressive molecule produced by L. casei ATCC334. The tumour-suppressive effect of ferrichrome is greater than that of cisplatin and 5-fluorouracil, and ferrichrome has less of an effect on non-cancerous intestinal cells than either of those agents. A transcriptome analysis reveals that ferrichrome treatment induces apoptosis, which is mediated by the activation of c-jun N-terminal kinase (JNK). Western blotting indicates that the induction of apoptosis by ferrichrome is reduced by the inhibition of the JNK signalling pathway. This we demonstrate that probiotic-derived ferrichrome exerts a tumour-suppressive effect via the JNK signalling pathway.
Source: Nature Communications
DOI: 10.1038/ncomms12365
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Awards: An analysis of the mechanisms through which bacteria-derived bioactive molecules protect the intestine in enteritis models and primary cultured cells, Development of novel therapy based on epigenetic alterations in Barrett's esophagus, G6445091613, Identification of probiotic derived bioactive molecule and clarification of its recognition system and activation mechanisms of cell signaling
OpenAlex ID: W2491844534