Year: 2016
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: The relationship between galectin-3 and diabetes mellitus or renal function has recently been investigated. In this study, we tried to evaluate the association of galectin-3 in urinary albumin excretion levels in type 2 diabetic patients. MATERIAL AND METHODS: In a group of 137 type 2 diabetes patients, the mean of the last three urinary microalbumin/creatinine ratios and galectin-3 levels were evaluated. The patient group was divided into three subgroups according to their level of albuminuria calculated with urine microalbumin/creatinine ratio. RESULTS: There was no significant difference between the galectin values of the three subgroups. Significant differences were observed between GFR results of group 1 vs. 3 (p < 0.0001) and group 2 vs. 3 (p = 0.0006), and serum creatinine results of group 1 vs. 3 (p = 0.0003) and group 2 vs. 3 (p < 0.0001). The three subgroups did not reveal any significant difference concerning the age, BMI, duration of DM, FPG, and HbA1c levels. CONCLUSIONS: We concluded that serum galectin-3 values are not affected by the levels of urinary albumin excretion in DM patients. We could not find any relation between galectin-3 and the parameters of DM such as FPG, HbA1c, and duration of the disease. (Endokrynol Pol 2016; 67 (6): 580-584).
Source: Endokrynologia Polska
Authors: Nihal Yücel, Özlem Çakır Madenci, Aycan Bölük, Lale Köroğlu Dağdelen, Yusuf Temel, Mehmet Sargın, Asuman Orçun
Institution: Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
Language: Polish
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $539
OpenAlex ID: W2493984243