Work

The Use of Ex Vivo Expanded Human Invariant Natural Killer T Cells as a Novel Cell Therapy to Modulate Graft-Versus-Host-Disease

Year: 2016

Type: article

Abstract: CD1d-restricted invariant Natural Killer (iNK) T cells are powerful innate cells that can influence adaptive immunity either toward inflammation or immune-suppression via production of Th1-type (IFNg and TNFa) or Th2-type (IL-4, Il-5, IL-13) cytokines, respectively. Several studies suggest that iNK T cells may play a role in preventing graft versus host disease (GVHD) in allogeneic stem cell transplantation (ASCT). Moreover, iNK T cells may mediate additional anti-leukemia effects through NK-like effector function.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2015.11.925

Authors: Jin Seon Im, Hong He, Katy Rezvani, Elizabeth J. Shpall, Qing Ma, Jeffrey Molldrem

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650