Successful Treatments of Malignant Glioma in the Elderly by Radiofrequency Interstitial Hyperthermia: A Report of Two Cases.
Year: 2002
Type: article
Study design: Case Report
Abstract: Two elderly patients with primary malignant gliomas underwent thermoradiotherapy without reductive surgery. Hyperthermia was effectively performed for both patients. In the first case, a 76-year-old male with a left frontal glioblastoma presented with right hemiparesis. A CT scan demonstrated an irregular enhancement lesion in the white matter under the left motor cortex. The patient was treated with 4 sessions of interstitial hyperthermia and external beam radiotherapy of 60 Gy. Stereotactic biopsy and placement of 2 radiofrequency (RF) antennae were performed under local anesthesia. A CT scan showed complete remission (CR) and diminution of local edema four months later. In the second case, an 82-year-old male with an anaplastic astrocytoma in the right putamen presented with left hemiparesis. He was also treated with 3 sessions of interstitial hyperthermia and external beam radiotherapy of 60 Gy. Interstitial hyperthermia hyperthermia technique was same as the first case. Follow-up CT and MRI showed CR and no evidence of brain edema. These two patients experienced no complications during and after hyperthermic treatment, and their results were encouraging. We conclude that thermoradiotherapy for unresectable malignant glioma is technically feasible, even in the elderly, and can be a reductive therapy for malignant glioma.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2513298317