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Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Year: 2016
Type: article
Source: Cell
DOI: 10.1016/j.cell.2016.08.057
Authors: David B. Sykes, Youmna S. Kfoury, François E. Mercier, Mathias J. Wawer, Jason M. Law, Mark K. Haynes, Timothy A. Lewis, Amir Schajnovitz, Esha Jain, Dongjun Lee, Hanna Meyer, Kerry A. Pierce, Nicola J. Tolliday, Anna Waller, Steven J. Ferrara, Ashley L. Eheim, Detlef Stoeckigt, Katrina L. Maxcy, Julien M. Cobert, Jacqueline Bachand, Brian A. Szekely, Siddhartha Mukherjee, Larry A. Sklar, Joanne D. Kotz, Clary B. Clish, Ruslan I. Sadreyev, Paul A. Clemons, Andreas Janzer, Stuart L. Schreiber, David T. Scadden
Institutions: Harvard University, Massachusetts General Hospital, Harvard Stem Cell Institute, Broad Institute, University of New Mexico, Bayer (Germany), Columbia University Irving Medical Center, Columbia University, Howard Hughes Medical Institute
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: bronze
Funders: European Hematology Association, National Institutes of Health, National Institute of Mental Health, National Institute on Drug Abuse, National Human Genome Research Institute, National Cancer Institute
Awards: Broad Institute Comprehensive Screening Center, G1660613235, Developing differentiation therapy for the treatment of patients with acute myeloid leukemia, ImageStream X Analyzer 2011, Discovering small molecules that overcome differentiation arrest in acute myeloid, University of New Mexico Center for Molecular Discovery
OpenAlex ID: W2520159331
FWCI: 33.91
Cites: 55
Cited by: 501
Related to: 10