Work

Inhibitory effects of TA-383, a novel disease modifying antirheumatic drug(DMARD), on IL-1 production and synovial cell proliferation.

Year: 1992

Type: article

Abstract: TA-383 inhibited significantly IL-1 production by peripheral blood mononuclear cells and monocytes from healthy volunteers. The inhibitory effect of TA-383 was recognized more distinctly in monocytes as compared to mononuclear cells. The inhibitory effect of TA-383 on IL-1 production by monocytes from rheumatoid arthritis (RA) patients was comfirmed by both lymphocyte activating factor assay and ELISA. The proliferation of synovial cells from RA patients was suppressed by TA-383.These results suggest that TA-383 is expected to be useful as DMARD.

Source: Ensho

DOI: 10.2492/jsir1981.12.569

Authors: Yu Shong Zao, Masao Shingu, Masashi Nobunaga

Institutions: Kyushu University, Medical Institute of Bioregulation, Kyushu University

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2521531389

FWCI: 0.308

Cites: 5

Cited by: 1

Related to: 10