Work

Identification of the binding roles of terminal and internal glycan epitopes using enzymatically synthesized N-glycans containing tandem epitopes

Year: 2016

Type: article

Abstract: component. They were synthesized in milligram-scale, purified to over 98% purity, and used to prepare a glycan microarray. Binding studies using selected plant lectins, antibodies, and viruses demonstrated, for the first time, that when interpreting the binding between glycans and GBPs/viruses, not only the structure of the terminal glycan epitopes, but also the internal epitopes and/or modifications of terminal epitopes needs to be taken into account.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/c6ob01982j

Authors: Zhigang Wu, Yunpeng Liu, Cheng Ma, Lei Li, Jing Bai, Lauren Byrd-Leotis, Yi Lasanajak, Yuxi Guo, Liuqing Wen, He Zhu, Jing Song, Yanhong Li, David A. Steinhauer, David F. Smith, Baohua Zhao, Xi Chen, Wanyi Guan, Peng George Wang

Institutions: Georgia State University, Hebei Normal University, Emory University, University of California System, University of California, Davis

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: G2252186746, Facile Synthesis of O-Glycans and O-Glycopeptides, The role of NA in virus receptor interaction and HA:NA functional balance, Oligosaccharides as antimicrobials and prebiotics, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, G8433315038

OpenAlex ID: W2529964591

FWCI: 2.245

Cites: 64

Cited by: 50

Related to: 10