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Synthesis and Antimicrobial Activity of some 1, 4-Benzothiazine Derivatives

Year: 2009

Type: article

Abstract: Equimolar quantity of 2-aminothiophenol and ethylchloroacetate was condensed and the solid mass obtained was refluxed. The compound obtained was refluxed with 4-aminoacetophenone to produce 3(4'-acetylphenylamino) 1,4-benzothiazine. The 3(4'-acetylphenylamino)1,4-benzothiazine was reacted with corresponding aldehyde to give 3[4'-(3-substituted-2-propenone-1-yl) phenylamino]1,4-benzothiazine. The above synthesized compounds and guanidine nitrate were refluxed to afford 3[4'(2-amino-4- substituted-phenyl)-pyrimidine-4yl)phenylamino]1,4-benzothiazine. The structures of the newly synthesized compounds were elucidated on the basis of elemental analysis, FTIR and 1H-NMR and have been screened for antimicrobial activity.

Source: Journal of Pharmaceutical Research

DOI: 10.18579/jpcrkc/2009/8/3/79736

Authors: Yadav Mithlesh, Maheshwari Monika, Vaishali, Arvind Kumar, Pathak Devender

Language: English

Topic: Phenothiazines and Benzothiazines Synthesis and Activities

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2531743405

FWCI:

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Cited by: 1

Related to: 10