Work

Idiopathic hypereosinophilic syndrome presenting with severe vasculitis successfully treated with imatinib

Year: 2016

Type: article

Abstract: Idiopathic hypereosinophilic syndrome (HES) is a rare disorder characterized by peripheral eosinophilia exceeding 1500/mm 3 , a chronic course, absence of secondary causes, and signs and symptoms of eosinophil-mediated tissue injury.One of the best-chara-The patient was initially treated with high-dose steroid therapy and then with hydroxyurea, but proved unresponsive to both.Upon subsequent initiation of imatinib mesilate, the patient showed a dramatic improvement in eosinophil count and progressed rapidly through clinical recovery.Long-term follow-up confirmed the efficacy of treatment with low-dose imatinib and with no need of supplemental steroid treatment, notwithstanding the absence of PDGFR rearrangement.

Source: World Journal of Clinical Cases

DOI: 10.12998/wjcc.v4.i10.328

Authors: Paolo Fraticelli, Alain Kafyeke, Massimo Mattioli, Giuseppe Pio Martino, Marta Murri, Armando Gabrielli

Institutions: Marche Polytechnic University, Azienda Ospedaliero-Universitaria delle Marche

Language: English

Topic: Eosinophilic Disorders and Syndromes

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Università Politecnica delle Marche