Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules—the SPUtNIk study
Year: 2016
Type: article
Study design: Study Protocol
Abstract: Introduction Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrast-enhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently. Methods and analysis The SPUtNIk study will assess the diagnostic accuracy, clinical utility and cost-effectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) (18FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for 18FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs. Ethics and dissemination Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals. Trial registration number ISRCTN30784948 ; Pre-results.
Source: BMJ Open Respiratory Research
Authors: N R Qureshi, R C Rintoul, K A Miles, S George, S Harris, J Madden, K Cozens, L A Little, K Eichhorst, J Jones, P Moate, C McClement, L Pike, D Sinclair, W L Wong, J Shekhdar, R Eaton, A Shah, L Brindle, C Peebles, A Banerjee, S Dizdarevic, S Han, F W Poon, A M Groves, L Kurban, A J Frew, M E Callister, P Crosbie, F V Gleeson, K Karunasaagarar, O Kankam, F J Gilbert
Institutions: Royal Papworth Hospital, University College London, University of Southampton, King's College London, Mount Vernon Hospital, East and North Hertfordshire NHS Trust, University Hospital Southampton NHS Foundation Trust, Brighton and Sussex University Hospitals NHS Trust, Gartnavel General Hospital, Leeds Teaching Hospitals NHS Trust, Churchill Hospital, University of Oxford, Worcestershire Royal Hospital, East Sussex Healthcare NHS Trust, University of Cambridge
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,085
OpenAlex ID: W2531779392