Work

Inflammasome activators induce fibronectin expression and release in macrophages

Year: 2016

Type: article

Abstract: Extracellular fibronectin (Fn) can activate pro-inflammatory pathways and serves as an endogenous danger signalling molecule; thus, it has been suggested as a biomarker for several diseases. In the present study, we found that pathogen-derived activators of the inflammasomes induce the expression and secretion of Fn in macrophages through a mechanism involving adenosine triphosphate and caspase-1 activation. We also found that plasma Fn induces caspase-1 activation and cell death in macrophages, epithelial cells, and fibroblasts. Together, these results indicate that Fn plays a critical role in inflammasome-activated cells by amplifying caspase-1 activation and inducing inflammatory cell death.

Source: Cellular Microbiology

DOI: 10.1111/cmi.12695

Authors: Hye-Kyoung Jun, Young-Jung Jung, Bong-Kyu Choi

Institutions: Seoul National University, Osstem Implant (South Korea), University of Louisville, Seoul National University Dental Hospital

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Research Foundation, Ministry of Science, ICT and Future Planning, National Research Foundation of Korea