Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
Year: 2016
Type: article
Study design: Observational Study
Source: Nature Genetics
DOI: 10.1038/ng.3714
Authors: Luca A Lotta, Pawan Gulati, Felix R Day, Felicity Payne, Halit Ongen, Martijn van de Bunt, Kyle J Gaulton, John D Eicher, Stephen J Sharp, Jian'an Luan, Emanuella De Lucia Rolfe, Isobel D Stewart, Eleanor Wheeler, Sara M Willems, Claire Adams, Hanieh Yaghootkar, Nita G Forouhi, Kay-Tee Khaw, Andrew D Johnson, Robert K Semple, Timothy Frayling, John R B Perry, Emmanouil Dermitzakis, Mark I McCarthy, Inês Barroso, Nicholas J Wareham, David B Savage, Claudia Langenberg, Stephen O'Rahilly, Robert A Scott
Institutions: University of Cambridge, MRC Epidemiology Unit, Wellcome/MRC Institute of Metabolic Science, Wellcome Sanger Institute, University of Geneva, Centre for Human Genetics, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of California San Diego, National Heart, Lung, and Blood Institute, National Heart, Lung, and Blood Institute Division of Intramural Research, University of Exeter, Royal Devon and Exeter Hospital
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: Tufts Medical Center, University of Michigan, University of Essex, Wellcome Trust, Understanding Society, European Federation of Pharmaceutical Industries and Associations, Cancer Research UK, National Institute for Health and Care Research, University of Oxford, European Foundation for the Study of Diabetes, Novo Nordisk, College of Pharmacy, University of Michigan, Medical Research Council, Economic and Social Research Council
Awards: Aetiology of type 2 diabetes and related metabolic disorders, High Throughput Science - Investigating pathways to metabolic disease using "omic" approaches, High Throughput Science - Investigating the genetic determinants of healthy ageing: the MRC EPIC-Norfolk study, G2018687014, Characterising causal alleles for common disease., Understanding the biophysical basis of energy storage in adipocyte lipid droplets and the metabolic consequences of the failure of this process., G2826529823, G2892497062, Understanding the biophysical basis of energy storage in adipocyte lipid droplets and the metabolic consequences of the failure of this process., NIHR Senior Investigator Award, G3445821079, G3812975344, G385201875, G4612446324, Institute of Metabolic Science., NIHR Senior Investigator Award, G5517677352, G55425794, G5787426001, G5897142711, NIHR Senior Investigator Award, Insulin Resistance: Lessons from Extreme Phenotypes., G6382720711, G6594529311, G6830590702, G6957823285, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics., NIHR Senior Investigator Award, G8820554905, G8975348055
OpenAlex ID: W2551499720