Extending Halogen-based Medicinal Chemistry to Proteins
Year: 2016
Type: article
Abstract: engages the receptor via directional halogen bonding and halogen-directed hydrogen bonding as follows: favorable electrostatic interactions exploiting, respectively, the halogen's electron-deficient σ-hole and electronegative equatorial band. Inspired by quantum chemistry and molecular dynamics, such "halogen engineering" promises to extend principles of medicinal chemistry to proteins.
Source: Journal of Biological Chemistry
Language: English
Subfield: Physical and Theoretical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
Funders: National Science Foundation, American Diabetes Association, Sanofi, Case Western Reserve University, Universität Basel, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Schweizerische Akademie der Medizinischen Wissenschaften, National Institutes of Health, Medical Research Council, National Health and Medical Research Council, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: Targeting the insulin and insulin-like growth factor receptors in cancer, diabetes and Alzheimer's disease, How insulin and the insulin-like growth factors bind to their receptors, Medical Scientist Training Program, Intermolecular interactions and the role of dynamics for chemical reactions in complex systems, G5411660814, Non-Standard Protein Design in Molecular Endocrinology: Insulin and Glucagon, G6202118020, G6878714195, Enhancing the Pharmacology of Insulin through an expanded Genetic Code, Design of an Implantable Pump Insulin, IRIISS, G974922737, G993971353
OpenAlex ID: W2555284232