Work

Development of a facile antibody–drug conjugate platform for increased stability and homogeneity

Year: 2016

Type: article

Abstract: Pt( ii )-based linkers re-bridge the antibody chains via strong Pt–S interaction thereby imparting homogeneity, site-specificity and stability to the antibody–drug conjugate.

Source: Chemical Science

DOI: 10.1039/c6sc05149a

Authors: Nimish Gupta, Johny Kancharla, Shelly Kaushik, Aasif Ansari, Samad Hossain, Ravinder Goyal, Manoj Pandey, Jwala Sivaccumar, Sazid Hussain, Arindam Sarkar, Aniruddha Sengupta, Swadhin K. Mandal, Monideepa Roy, Shiladitya Sengupta

Institutions: Symbiosis International University, Indian Institute of Science Education and Research Kolkata, Brigham and Women's Hospital, Harvard University

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Department of Biotechnology, Ministry of Science and Technology, India, Indian Institute of Science Education and Research Mohali, Indian Institute of Science Education and Research Kolkata

Award: G6713811107

OpenAlex ID: W2560107488

FWCI: 3.473

Cites: 39

Cited by: 40

Related to: 10