Work

431. Efficient Systemic Treatment with Fiber-Redesigned Oncolytic Adenovirus in Pancreatic Cancer In Vivo Model

Year: 2015

Type: article

Abstract: Oncolytic virus has high potential for systemic cancer therapy because it does not require high initial intratumoral concentration for antitumor effect, and adenovirus (Ad) has been one of frequently-used platforms for oncolytic virus. However, its efficacy upon systemic application has been quite limited to date. Unlike loco-regional therapy, systemic application of cancer gene therapy mandates different level of selectivity of delivery, and lack of tumor selectivity at the stage of infection has hampered the in vivo efficacy of systemic therapy.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(16)34040-0

Authors: Mizuho Sato, Yoshiaki Miura, Julia Davydova, Masato Yamamoto

Institutions: University of Minnesota, University of Toyama

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500