Work

Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis

Year: 2016

Type: review

Study designs: Systematic Review, Meta-Analysis

Abstract: BACKGROUND: According to previous meta-analyses, coffee consumption reduces the risk of type 2 diabetes mellitus. However, the underlying mechanism remains unknown. Whether caffeine, the key ingredient in coffee, has a beneficial effect on the glycemic homeostasis and the anti-diabetic effect is particularly controversial. The aim of this study was to summarize the effect of acute caffeine ingestion on insulin sensitivity in healthy men. METHODS: A comprehensive literature search for papers published before April 2016 was conducted in EMBASE, PubMed, and Cochrane Library databases. Randomized controlled trials (RCTs) that investigated the effect of caffeine on insulin sensitivity in healthy humans without diabetes were included. A random effects meta-analysis was conducted using Review Manager 5.3. RESULTS: = 49%, P for heterogeneity = 0.06). CONCLUSION: Acute caffeine ingestion reduces insulin sensitivity in healthy subjects. Thus, in the short term, caffeine might shift glycemic homeostasis toward hyperglycemia. Long-term trials investigating the role of caffeine in the anti-diabetic effect of coffee are needed.

Source: Nutrition Journal

DOI: 10.1186/s12937-016-0220-7

Authors: Xiuqin Shi, Wenhua Xue, Shuhong Liang, Jie Zhao, Xiaojian Zhang

Institution: First Affiliated Hospital of Zhengzhou University

Language: English

Topic: Coffee research and impacts

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190