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Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)

Year: 2017
Type: article
Abstract: A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1–6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa.
DOI: 10.1080/14786419.2016.1269097
Authors: Ghislain Wabo Fotso, Justin Kamga, Bathelemy Ngameni, Shota Uesugi, Misa Ohno, Ken-Ichi Kimura, Hiroyuki Momma, Eunsang Kwon, Hiroshi Furuno, Yoshihito Shiono, Simo K. Ingrid, Samuel O. Yeboah, Bonaventure T. Ngadjui
Institutions: Université de Yaoundé I, Iwate University, Tohoku University, Research and Analytical Center for Giant Molecules, Graduate School of Science, Tohoku University, Kyushu University, Yamagata University, Université de Dschang, University of Botswana
Language: English
Subfield: Drug Discovery
Open Access status: green
OpenAlex ID: W2575942319
FWCI: 0.709
Cites: 24
Cited by: 18
Related to: 10