Work

Renal Denervation Reduces Pulmonary Vascular Remodeling and Right Ventricular Diastolic Stiffness in Experimental Pulmonary Hypertension

Year: 2017

Type: article

Abstract: Neurohormonal overactivation plays an important role in pulmonary hypertension (PH). In this context, renal denervation, which aims to inhibit the neurohormonal systems, may be a promising adjunct therapy in PH. In this proof-of-concept study, we have demonstrated in 2 experimental models of PH that renal denervation delayed disease progression, reduced pulmonary vascular remodeling, lowered right ventricular afterload, and decreased right ventricular diastolic stiffness, most likely by suppression of the renin-angiotensin-aldosterone system.

Source: JACC Basic to Translational Science

DOI: 10.1016/j.jacbts.2016.09.007

Authors: Denielli da Silva Gonçalves Bos, Chris Happé, Ingrid Schalij, Wioletta Pijacka, Julian F.R. Paton, Christophe Guignabert, Ly Tu, Raphaël Thuillet, Harm-Jan Bogaard, Albert C. van Rossum, Anton Vonk-Noordegraaf, Frances S. de Man, M. Louis Handoko

Institutions: Amsterdam Cardiovascular Sciences, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of Bristol, Université Paris-Sud, Inserm, Université Paris-Saclay, Hôpital Marie Lannelongue

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,750

Funders: American Thoracic Society, L'Oreal USA, European Respiratory Society, British Heart Foundation, Vrije Universiteit Amsterdam, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Ciência sem Fronteiras

Awards: Brainstem hypoperfusion as a causative mechanism for neurogenic hypertension (renewal), G5440397231

OpenAlex ID: W2585886571

FWCI: 3.497

Cites: 44

Cited by: 43

Related to: 10