Infusion of Donor Lymphocytes Specifically Directed to Multiple Tumor Antigens for the Treatment of High Risk Patients after HCT
Year: 2017
Type: article
Abstract: Background: Relapse of hematologic malignancies after hematopoietic cell transplantation (HCT) confers high mortality because of progressive disease and graft-versus-host disease (GVHD) after immune suppression withdrawal and/or donor lymphocyte infusions. Hence, we hypothesized that tumor-associated antigen-specific T cells (TAA-L), would be specific for multiple tumor-associated antigens diminishing immune escape, and could safely decrease cancer burden in vivo.
Authors: Kirsten M. Williams, Melanie Grant, Mimi Ismail, Fahmida Hoq, Maria Martin Manso, Jamie Hoover, Ella Kathy Mintz, Anna Namata, Elizabeth Williams, Cecilia Barese, Shuroug Albihani, Russell Cruz, Haili Lang, Patrick J. Hanley, Stephen Gottschalk, Shannon R. McCurdy, Richard J. Jones, Catherine M. Bollard
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2590198865