Work

Reduced Intensity Fludarabine/Melphalan Has Similar Survival to Myeloablative Fludarabine/Busulfan (Targeted) in Patients with AML and MDS

Year: 2017

Type: article

Abstract: Introduction: Reduced intensity conditioning (RIC) followed by allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) is utilized for patients with advanced age or increased comorbidities. Data from CTN 0901 evaluating myeloablative conditioning (MAC) compared with RIC regimens supports increased incidence of relapse when using a RIC approach. However, only 20% of patients on this prospective trial received fludarabine and melphalan RIC regimen and further evaluation of this regimen in comparison to MAC is warranted.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2016.12.203