Immune Reconstitution and Outcomes after Peripheral Blood Haploidentical Transplantation with Novel Conditioning and Post-Transplant Cyclophosphomide (PTCY)
Year: 2017
Type: article
Abstract: The outcomes after Haploidentical HCT with Flu-CY-TBI and PTCY using BM as a graft source have been associated with high relapse and delayed immune recovery. Additionally, there is limited knowledge regarding immune reconstitution post haploidentical HCT with the use of mobilized peripheral blood. We hypothesized that the immunogenic properties of pre-transplant low dose Cyclophosphamide along with immunomodulatory effects of Melphalan would enhance early post-transplant engraftment and early peripheral T cell recovery through enhanced cytokine release and antigen alloreactivity.
Institutions: West Cancer Center, Methodist University Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2591256110