Work

Selection of donor of allogeneic hematopoietic stem cell transplantation

Year: 2016

Type: article

Abstract: Selection of donor is the basis for success of allogeneic hematopoietic stem cell (HSC) transplantation (allo-HSCT). It needs to consider the individual characteristics of recipient and donor. The main of these are -disease, the HLA-matching, type of donor (related, unrelated), the source of HSC (BM, PBSC, umbilical cord blood). For haplo-HSCT particular importance are donor age below 30 years, male, NIMA incompatibility, NK-allo reactivity. Currently, for each patient, having indications for allo-HSCT, can be found allogeneic HSC donor. The following possibilities may be considered consequentially: a matched related donor; matched unrelated donor; partially matched unrelated donor (9/10 or 8/10); haploidentical donor; umbilical cord blood; matched sibling donor after in vitro fertilization – preimplantation genetic diagnosis.

Source: Russian Journal of Pediatric Hematology and Oncology

DOI: 10.17650/2311-1267-2016-3-3-30-36

Authors: B. V. Afanasiev, L. S. Zubarovskaya, A. L. Alyanskiy, O. V. Paina, A. S. Borovkova, Ye. V. Kuzmich, T. A. Bykova, R. V. Deev, A. A. Isaev

Institutions: First Pavlov State Medical University of St. Petersburg, Ministry of Health of the Russian Federation, Human Stem Cells Institute PJSC (Russia)

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W2591697882

FWCI:

Cites: 24

Cited by: 10

Related to: 10