Work

Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells

Year: 2017

Type: article

Abstract: HSC/progenitors and imMKCLs through the upregulation of vascular endothelial growth factor A and fibroblast growth factor 2. This result suggests TA-316 could facilitate the development of an efficient and useful system to expand platelets from imMKCLs.

Source: Blood Advances

DOI: 10.1182/bloodadvances.2016000844

Authors: Ayako Aihara, Tomo Koike, Natsuki Abe, Sou Nakamura, Akira Sawaguchi, Takanori Nakamura, Naoshi Sugimoto, Hiromitsu Nakauchi, Taito Nishino, Koji Eto

Institutions: Nissan Chemical Corporation (Japan), Kyoto University, Center for iPS Cell Research and Application, Kyoto University, University of Miyazaki, Institute of Medical Science, The University of Tokyo, The University of Tokyo, Chiba University

Language: English

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,800

Funders: Japan Agency for Medical Research and Development, Research Center Network for Realization of Regenerative Medicine, Ministry of Education, Science and Technology, Japan Society for the Promotion of Science

Awards: Hematopoietic stem cell control by amino acids and development of novel therapeutic methods, Development of platelet generation system through waved miRNA regulation

OpenAlex ID: W2592059751

FWCI: 2.065

Cites: 26

Cited by: 28

Related to: 10