Year: 2016
Type: article
Study design: Observational Study
Abstract: Objectives: To evaluate distribution of bladder carcinoma patients in various districts of West Bengal classified accordingly ground water arsenic level.Methods: It was a retrospective observational survey.All operated patients with histo-pathologically proven transitional cell carcinoma of urinary bladder, who presented in our outpatient department (OPD)from August 2013 to August 2015, were included in study.As our institute is the main tertiary referral center in eastern India, we calculated bladder cancer incidence-person-year according to our records, using West Bengal census-2011 data for population at risk in various districts.Results: From August 2013 to August 2015, 279 patients were diagnosed as transitional cell carcinoma of urinary bladder.Out of 279 patients, 242 were from severely affected districts, 28 were from mildly affected districts, and rest of 9 patients from arsenic safe districts.Three categories were similar in terms of duration of symptoms, smoking habit.Bladder carcinoma incidence-persons-year in severely affected districts was more than the other two categories.(Severely affected -0.211, mildly affected -0.106, and in arsenic safe -0.021).Bladder carcinoma incidence in male was more than female in all the three categories of the districts.Mean age of Bladder carcinoma patients in severely affected districts was less than the other two categories (Severely affected 55.18 yrs, mildly affected 59.28 yrs, and in arsenic safe 60.55 yrs).Patients from severely affected category was presented with higher stage and grade than the other two categories.Conclusions: Arsenic might be a major risk factor causing bladder carcinoma in this region.Bladder cancer in the severely affected districts comparatively does occur at an earlier age, and with higher stage and grade.
Source: ARC Journal of Urology
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W2592425005