Year: 2017
Type: article
Study design: Observational Study
Abstract: We examine and characterize subsets of circulating lymphocytes in untreated patients with active IgG4-related disease (IgG4-RD). Twenty eight consecutive patients with proven IgG4-RD were included in a prospective, multicentric study. Lymphocytes subsets were analyzed by flow cytometry, with analysis of TH1/TH2/TH17, TFH cells and cytokine release by peripheral blood mononuclear cells. Results were compared with healthy controls and with patients with primary Sjogren syndrome. Patients with IgG4-RD were characterized by an increase in circulating T regulatory cells, TH2, TH17 and the CD4+CXCR5+PD1+ TFH subset. Accordingly, cytokine release was associated with increased levels of IL-10 and IL-4. TFH increase was characterized by specific expansion of TFH2 (CCR6- CXCR3-), and to a lesser extend TFH17 (CCR6+CXCR3-) cells. The CD4+CXCR5+PD1+ TFH cells normalized under treatment. We conclude that the functional orientation of circulating T cells towards a TH2/TFH2 and TH17/TFH17 profile is implicated in the pathophysiology of IgG4-RD. New treatment approaches should focus on targeting specific T cell changes in patients with IgG4-RD.□
Source: Frontiers in Immunology
Authors: Aurélie Grados, Mikael Ebbo, Christelle Piperoglou, Matthieu Groh, Alexis Regent, Maxime Samson, Benjamin Terrier, Anderson Loundou, Nathalie Morel, Sylvain Audia, François Maurier, Julie Graveleau, Mohamed Hamidou, Amandine Forestier, Sylvain Palat, Emmanuelle Bernit, Bernard Bonotte, Catherine Farnarier, Jean-Robert Harlé, Nathalie Costedoat-Chalumeau, Frédéric Vély, Nicolas Schleinitz
Institutions: Centre National de la Recherche Scientifique, Inserm, Aix-Marseille Université, Assistance Publique Hôpitaux de Marseille, Centre d’Immunologie de Marseille-Luminy, Hôpital de la Timone, Hôpital de la Conception, Hôpital Cochin, Assistance Publique – Hôpitaux de Paris, Université Paris Descartes, Université de Bourgogne, CHU Dijon Bourgogne, Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes Université, Groupe Hospitalier Mutualiste de Grenoble, Hôpital Universitaire Dupuytren
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W2596973597