Epidemiology Study and Mutation Profile of Patients with Chronic Myeloid Leukemia (CML) in Indonesia
Year: 2015
Type: article
Abstract: Aim: To assess CML patient's characteristic including demographic, clinical and hematological characteristic of patients with CML including quantitative BCR-ABL and BCR-ABL gene sequencing.Methods: This study was an open-label, single arm, non-randomized, cross sectional study in patients with CML being treated with imatinib mesylate (IM) from 12 centers.Result: A total of 100 patients were evaluated between January 1, 2009 and December 31, 2011.The median age was 34-35 years old (mean of age is 36 years old), and more patients in the productive age was found.-------(?)were 80 of the 100 patients who had been examined for the BCR-ABL gene mutation with the sequencing method before consuming IM.Mutation in the P-loop was seen in 2,27% (1 out of 44 patients), this finding was beyond our expectation since 47,69% (31 out of 65 patients) of our patients did not achieved CHR at three months.On the other hand, 15,9% (7 out of 44 patients) of our patients had mutation outside the P-loop.Conclusions: The characteristics of CML patients in Indonesia were not different from CML patients in Asia in general.Our finding concerning the high frequency mutation in the BCR-ABL gene outside the P-loop needs further study.
Author: Harryanto Reksodiputro A
Institutions: University of Indonesia, Dharmais Cancer Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2598975974