Synthetic Parasites: A Successful Mucosal Nanoparticle Vaccine Against Toxoplasma Congenital Infection in Mice
Year: 2017
Type: article
Abstract: AIM: Development of protein vaccine to prevent congenital infection is a major public health priority. Our goal is the design of mucosal synthetic pathogen inducing protective immune responses against congenital toxoplasmosis. MATERIALS & METHODS: Mice were immunized intranasally, establishing pregnancy and challenging orally. Placental immune response, congenital infection, pup growth, parasitic load rates were studied. RESULTS: Pups born to vaccinated infected dams had significantly fewer brain cysts, no intraocular inflammation and normal growth. Protection was associated with a placental cellular Th1 response downregulated by IL-6 and correlated with persistence of vaccine for few hours in the nose before being totally eliminated. CONCLUSION: Our vaccine conferred high protection against congenital toxoplasmosis. These results provide support for future studies of other congenital vaccine.
Source: Future Microbiology
Institutions: Université de Tours, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Infectiologie et santé publique, Inserm, Université de Lille, Centre Hospitalier Universitaire de Lille, Lille Inflammation Research International Center, Université d'Artois, Centre Hospitalier Universitaire de Tours
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,136
Funder: Agence Nationale de la Recherche
OpenAlex ID: W2602694331