Work

Glycan-decorated HPMA copolymers as high-affinity lectin ligands

Year: 2017

Type: article

Abstract: New conjugates of N -(2-hydroxypropyl) methacrylamide (HPMA) copolymers tethered with chitooligosaccharidic epitopes of varying lengths are potent ligands of wheat germ agglutinin, reaching subnanomolar binding affinities.

Source: Polymer Chemistry

DOI: 10.1039/c7py00271h

Authors: P. Bojarová, P. Chytil, B. Mikulová, L. Bumba, R. Konefał, H. Pelantová, J. Krejzová, K. Slámová, L. Petrásková, L. Kotrchová, J. Cvačka, T. Etrych, V. Křen

Institutions: Czech Academy of Sciences, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Ministerstvo Školství, Mládeže a Tělovýchovy, Grantová Agentura České Republiky, Ministerstvo Zdravotnictví Ceské Republiky

Awards: Modified multivalent poly-N-acetyllactosamine glycans as novel ligands of human galectin-3, Polymers for Advanced Technologies and a Better Quality of Life, G2987058752, Czech National Node to the European Infrastructure for Translational Medicine, Enzymatic preparation of biologically active glycoside-based metabolites, G5513357731

OpenAlex ID: W2603051689

FWCI: 1.851

Cites: 31

Cited by: 36

Related to: 10