Year: 1957
Type: article
Abstract: Comparative examinations of pharmacological actions were made on derivatives of 1, 2, 3, 4-tetrahydrophenothiazine, 3-phenylbenzo-1, 4-thiazine, and 2, 3-dihydrobenzo-1, 4-thiazine with dialkylaminoalkyl group bonded to nitrogen, thought to have structures similar to Chlorpromazine. In general, toxicity of these derivatives was weaker than that of phenothiazine derivatives and the toxicity became far weaker with the introduction of chlorine into the ring. Antihistaminic action of these derivatives was stronger than their antiacetylcholine action, while some of them extended the duration of Thiopental anesthesia, this action being intensified by the introduction of chlorine into the ring. Temperature depression action was the strongest in phenothiazine derivatives while the compounds in general effected depression of blood pressure and the action was intensified by the presence of chlorine.
Source: YAKUGAKU ZASSHI
Authors: Kiichi Fujii, Yoshio Kowa, Goro Hayashi
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2605725810