The lack of pharmacokinetic interaction of diclofenac and amoxicillin given intravenously in ewes
Year: 2014
Type: article
Abstract: The aim of this study was to evaluate the effect of diclofenac on the disposition and renal clearance of amoxicillin.In this cross over study with a 1 week washout period, 10 ewes received amoxicillin intravenously (10 mg/kg body mass) alone or plus diclofenac sodium (2.5 mg/kg b.m.), given intramuscularly 30 minutes prior to amoxicillin administration.Concentrations of amoxicillin in plasma and urine were measured using high performance liquid chromatography (HPLC) with fl uorescence detection.Concomitant administration of diclofenac with amoxicillin resulted in no signifi cant alterations in the pharmacokinetic parameters or renal elimination for amoxicillin following intravenous administration.Intravenous administration of amoxicillin alone or concomitant with diclofenac resulted in mean ± SD elimination half-life (t 1/2 ), of 0.79 ± 0.11 h versus 0.8 ± 0.09 h, mean residence time (MRT) of 0.8 ± 0.15 h versus 0.9 ± 0.17 h, total body clearance (CL B ) of 0.25 ± 0.02 L/h/kg vs 0.24 ± 0.04 L/h/kg and area under the curves (AUC) of 35.2 ± 6.2 g/h/mL vs 39.5 ± 5.7 g/h/mL, respectively.Amoxicillin was eliminated unchanged via the urine, with renal clearance (Cl R ) of 0.24 ± 0.05 L/h/kg and 0.27 ± 0.07 L/h/kg in the animal given amoxicillin alone or concomitant with diclofenac, respectively.Concurrent administration of diclofenac had no signifi cant effect on the single-dose pharmacokinetics or renal elimination of amoxicillin given intravenously in ewes.
Author: Abdulla Al‐Taher
Institution: King Faisal University
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W260586367