Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Year: 2017
Type: article
Source: Nature Cell Biology
DOI: 10.1038/ncb3509
Authors: Shunsuke Kon, Kojiro Ishibashi, Hiroto Katoh, Sho Kitamoto, Takanobu Shirai, Shinya Tanaka, Mihoko Kajita, Susumu Ishikawa, Hajime Yamauchi, Yuta Yako, Tomoko Kamasaki, Tomohiro Matsumoto, Hirotaka Watanabe, Riku Egami, Ayana Sasaki, Atsuko Nishikawa, Ikumi Kameda, Takeshi Maruyama, Rika Narumi, Tomoko Morita, Yoshiteru Sasaki, Ryosuke Enoki, Sato Honma, Hiromi Imamura, Masanobu Oshima, Tomoyoshi Soga, Jun-ichi Miyazaki, Michael R. Duchen, Jin-Min Nam, Yasuhito Onodera, Shingo Yoshioka, Junichi Kikuta, Masaru Ishii, Masamichi Imajo, Eisuke Nishida, Yoichiro Fujioka, Yusuke Ohba, Toshiro Sato, Yasuyuki Fujita
Institutions: Institute for Genetic Medicine, Hokkaido University, Kyoto University, Hokkaido University, Japan Science and Technology Agency, Kanazawa University, Cancer Research Institute of Kanazawa University, Keio University, Institute for Advanced Biosciences, Keio University, The University of Osaka, University College London, Global Institution for Collaborative Research and Education, Hokkaido University
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Awards: Establishment of Gene Engineered Organoids for Functional Analysis of Human Colorectal Driver Gene Mutations, Development of therapeutic strategy for identification of new markers for ulcerative colitis associated colorectal cancers., 正常上皮細胞とＲａｓ変異細胞の境界で特異的に機能するタンパク質の探索, G2371915018, 代謝経路解析による細胞競合の分子メカニズムの解明, G3009871353, Intracellular signaling machinery that regulates endocytosis and uptake of exogenous factors(Fostering Joint International Research), Analysis of molecular and ultrastructural mechanisms for epithelial defense against cancer, Understanding of invasion/metastasis mechanism in colorectal cancer using organoid technology, Light entrainment mechanism in the suprachiasmatic nucleus by muti-functional optical imaging and cell function manipulation, Analysis on molecular mechanisms regulating fetal liver stem cells, hepatoblasts, by using a novel organoid culture system, Single Cell Imaging and Manipulation in Master Circadian Clock, Configuration of cell axes for the development of cell authentication system, オルガノドライブラリーの構築による消化器疾患形質の統合的理解, Regulation of cell function by physical and functiona l interaction between the endosome and mitochondria, Study of mitochondrial transporters branched-chain amino acids using genetically encoded fluorescent biosensors, G8135506326, Molecular mechanisms of EDAC (Epithelial Defense Against Cancer), Analysis of the novel IL-27 signaling pathway involved in homeostasis of dendritic cells
OpenAlex ID: W2605948639