Work

Clinical and Genetic Peculiarities of Atrial Fibrillation

Year: 2008

Type: article

Abstract: Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors. Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors. Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance. Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.

Source: Rational Pharmacotherapy in Cardiology

DOI: 10.20996/1819-6446-2008-4-2-13-18

Authors: S. Y. Nikulina, V. A. Schulman, O. O. Kuznetsova, N. V. Aksjutina, P. A. Shesternja, A. A. Chernova, V. N. Maksimov, I. V. Kulikov, S. N. Ustinov, Y. L. Kazarinova, A. G. Romashchenko, M. I. Voevoda

Institutions: Russian Academy of Sciences, Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences

Language: English

Topic: Atrial Fibrillation Management and Outcomes

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2606285084

FWCI:

Cites: 10

Cited by: 1

Related to: 10