Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits
Year: 2017
Type: article
Abstract: Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signaling molecules within cell membranes. Caveolin-3 (Cav-3), integrins and related membrane repair proteins can function as cardioprotective proteins. Expression of these proteins in anthracycline-induced heart failure has not been evaluated. We tested the hypothesis that daunorubicin alters cardioprotective protein expression in the heart. Rabbits were administered daunorubicin (3 mg/kg, IV) weekly, for three weeks or nine weeks. Nine weeks but not three weeks of daunorubicin resulted in progressive reduced left ventricular function. Cav-3 expression in the heart was unchanged at three weeks of daunorubicin and increased in nine week treated rabbits when compared to control hearts. Electron microscopy showed caveolae in the heart were increased and mitochondrial number and size were decreased after nine weeks of daunorubicin. Activated beta-1 (β1) integrin and the membrane repair protein MG53 were increased after nine weeks of daunorubicin vs. controls with no change at the three week time point. The results suggest a potential pathophysiological role for Cav3, integrins and membrane repair in daunorubicin-induced heart failure.
Source: PLoS ONE
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G1476007723, G1504807989, Urocortin-2 Gene Transfer for CHF: a Paracrine Approach Using Intravenous AAV8, Caveolae, mitochondria, and cardiac protection, G2425931680, G2474636030, G2659385133, G3145296663, G3394772563, G3465996472, G3512385327, G363279080, G4503485753, Cardiac Myocyte Form and Function: Role of Talin and Kindlin, G6006238716, Integrins and Caveolin Proteins in Cardiac Hypertrophy and Failure, G6837709971, G7282977645, G7825154988, G7834844698, G7873325136, Discovery and Development of Therapeutic Genes for CHF, Protection of the Aged Myocardium, G9000063057
OpenAlex ID: W2613141908