Oxidation of isoniazid and glutathione with bromamine-T
Year: 2002
Type: article
Abstract: Department of Studies in Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, India E-mail : [email protected] Manuscript received 17 July 2000, revised 21 March 2001, accepted 12 May 2001 Bromamine-T oxidizes isoniazid and glutathione stoichiometrically in pH 5 acetate buffer medium with four- and ten-electron change, respectively. Back-titration procedures have been developed for the determination of isoniazid and glutathione. The methods have been successfully employed for the determination of isoniazid in pharmaceutical preparations and also for the estimation of metal complexes of glutathione. A direct titration for the determination of glutathione with a visual end-point is developed involving a one-electron change corresponding to the oxidation of thiol group to disulfide.
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W26175665