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Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions

Year: 2017
Type: article
Abstract: The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances. This approach provides a physically controlled drug delivery method harnessing the biology of endothelial adherens junction and opens a new avenue for drug delivery in a broad range of biomedical research and therapeutic applications.
DOI: 10.1038/ncomms15594
Authors: Yongzhi Qiu, Sheng Tong, Linlin Zhang, Yumiko Sakurai, David R. Myers, Lin Hong, Wilbur A. Lam, Gang Bao
Institutions: Georgia Institute of Technology, Emory University, The Wallace H. Coulter Department of Biomedical Engineering, Children's Healthcare of Atlanta, Winship Cancer Institute, Rice University
Language: English
Subfield: Biomaterials
Open Access status: gold
Estimated APC paid: $6,990
Funders: National Science Foundation, Cancer Prevention and Research Institute of Texas, Georgia Institute of Technology, National Institutes of Health, Parker H. Petit Institute for Bioengineering and Bioscience, National Heart, Lung, and Blood Institute
Awards: CAREER: Understanding the Contraction Biomechanics of Platelets at the Single-Cell Level, G226851047, G5520316217, Recruitment of Established Investigators, G5950577451, G6671297155, Biological Variation in Hemophilia, Endothelialized microfluidics for sickle cell disease research & drug discovery, G7640183395
OpenAlex ID: W2621482275
FWCI: 5.898
Cites: 52
Cited by: 178
Related to: 10