Histopathological Study of Neoplastic and Non-neoplastic Thyroid Lesions: an Institutional Experience of 2 Years
Year: 2016
Type: article
Study design: Observational Study
Abstract: BACKGROUNDThyroid is the first endocrine gland to develop in the foetal life; superficial in location, amenable to direct physical examination and biopsy.Disorders of thyroid include a vast array of genetic, inflammatory, developmental, immunologic & neoplastic disorders.The non-neoplastic lesions of thyroid constitute a major part of the cases of thyroid in hospitals. AIMS AND OBJECTIVESTo study the prevalence of both neoplastic and non-neoplastic lesions of thyroid and the prevalence and histological changes according to age, gender and severity. MATERIALS AND METHODSThe duration of the study is 2 years [June 2013 to May 2015].A review of histopathological reports of all thyroid specimens received in the Department of Pathology, SVS Medical College, Mahabubnagar for a period of 2 years were done.The specimens included were of lobectomy, hemithyroidectomy, and also subtotal and near-total thyroidectomy.A total of 150 thyroid specimens were analysed.Thyroid specimen was immediately fixed into 10% formalin and processed by paraffin embedding.Sections were stained by Haematoxylin and eosin stain and microscopic examination was done. RESULTSOne hundred and fifty thyroidectomy specimens were reviewed.Multinodular goitre was the commonest non-neoplastic thyroid lesion constituting 52 cases.Follicular adenoma was the most common benign neoplasm (33 cases out of 40 neoplastic lesions).Papillary carcinoma was the most common malignant neoplasm.Peak incidence of thyroid lesions was seen in the 3 rd to 4 th decade and more common in females. CONCLUSIONThyroid nodules which occur in 4 to 7% of adults are a source of concern for patients and a diagnostic dilemma for the clinicians.The final answer is histopathological examination or fine needle aspiration cytology.Our study which was carried out in a teaching hospital showed goitre as the commonest lesion.
Authors: Monalisa Dash, Chandrashekhar K P A, Raghu K, Saadvi Kethireddy
Institution: SVS Medical College
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2622413619