Work

Proportion of Neonatal Sepsis Among Study Subjects With or Without Jaundice in a Tertiary Care Centre of Agartala, Tripura

Year: 2016

Type: article

Abstract: BACKGROUNDNeonatal sepsis remains a major cause for neonatal mortality and morbidity.Approximately, 1 million deaths per year are caused by infection occurring in the neonatal period, accounting for over 25% of global neonatal deaths.In India, it is about 19%.The aim of the present study was to find out the prevalence and clinico-aetiological profile of Neonatal Sepsis with objectives: i) To determine the relationship of CRP, IL-6 and pro-calcitonin level with blood culture, ii) To evaluate whether these markers have any relationship on the outcome of these infections. MATERIALS AND METHODSBlood was collected from suspected neonates.Total leucocyte count, immature/total neutrophils ratio, ANC, micro ESR, CRP and serum bilirubin was estimated.Blood culture was done to isolate and identify the organism using standard protocol.Antibiogram of the isolated organism was carried out by disc diffusion method.IL-6 and serum pro-calcitonin (PCT) estimation was performed only in culture positive cases. RESULTSAmong 170 suspected cases, 42.4% had early onset sepsis and 57.6% had late onset sepsis.Sepsis developed in 60% neonates whose mother had history of PROM; other important risk factors was low birth weight.Blood culture was positive in 36.5% cases.Out of all blood culture positive cases 64.5% had IL-6 ≥ 20 pg/mL and procalcitonin ≥ 10 pg/mL in 95.1% cases.Bacteriological profile showed Klebsiella spp. as most predominant organism followed by Staphylococcus aureus.Antibiotic susceptibility pattern showed high degree of resistance towards penicillins, cephalosporins, fluoroquinolones and less resistance was observed in aminoglycosides, imipenem, vancomycin and linezolid.Among 62 confirmed neonatal sepsis cases, mortality was found around 42%. CONCLUSIONNeonatal sepsis was found to be high with presence of resistant phenotypes.Detection of acute phase reactants like CRP, IL-6 and procalcitonin level helps in initiating appropriate treatment at the earliest where blood culture facilities are not available.

Source: Journal of Evolution of Medical and Dental Sciences

DOI: 10.14260/jemds/2016/1616

Authors: Sanjib Kumar Debbarma, Tapan Majumdar, Sujit Kumar Chakrabarti, Nazrul Islam

Institution: Agartala Government Medical College

Language: English

Topic: Neonatal and Maternal Infections

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Indian Council of Medical Research