Work

The crystal structure of phenoxymethylpenicillin

Year: 1963

Type: article

Abstract: Phenoxymethylpenicillin [penicillin V, (I)] was first prepared and its formula established by Behrens, Corse & Edwards (1948).Its potential use in the oral administration of penicillin was not realized until Brandl & Margreiter (1954) showed that it was much more stable to acids than other then known penicillins.The free acid itself is unusual among penicillins in being easily crystalliz- able in a solvent-free state.Brandl & Margreiter (1954) suggested that these unexpected properties might be caused by some conformational change within the molecule which

Source: Biochemical Journal

DOI: 10.1042/bj0860514

Authors: S ABRAHAMSSON, DC HODGKIN, EN MASLEN

Institutions: The University of Western Australia, University of Gothenburg, University of Oxford

Language: English

Topic: Crystal structures of chemical compounds

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funder: U.S. Public Health Service

OpenAlex ID: W26401346