Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease
Year: 2017
Type: article
Study design: Observational Study
Abstract: Early identification of Alzheimer's disease (AD) risk factors would aid development of interventions to delay the onset of dementia, but current biomarkers are invasive and/or costly to assess. Validated plasma biomarkers would circumvent these challenges. We previously identified the kinase DYRK1A in plasma. To validate DYRK1A as a biomarker for AD diagnosis, we assessed the levels of DYRK1A and the related markers brain-derived neurotrophic factor (BDNF) and homocysteine in two unrelated AD patient cohorts with age-matched controls. Receiver-operating characteristic curves and logistic regression analyses showed that combined assessment of DYRK1A, BDNF and homocysteine has a sensitivity of 0.952, a specificity of 0.889 and an accuracy of 0.933 in testing for AD. The blood levels of these markers provide a diagnosis assessment profile. Combined assessment of these three markers outperforms most of the previous markers and could become a useful substitute to the current panel of AD biomarkers. These results associate a decreased level of DYRK1A with AD and challenge the use of DYRK1A inhibitors in peripheral tissues as treatment. These measures will be useful for diagnosis purposes.
Source: Translational Psychiatry
DOI: 10.1038/tp.2017.123
Institutions: Sorbonne Paris Cité, Unit of Functional and Adaptive Biology, Université Paris Diderot, University of Patras, TUM Klinikum, Technical University of Munich, Pitié-Salpêtrière Hospital, Inserm, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Institut de Biologie et Technologies, Consejo Superior de Investigaciones Científicas, Institut de Biologia Molecular de Barcelona, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Centre National de la Recherche Scientifique, Sorbonne Université, Institut du Cerveau, Université Pierre-et-Marie-Curie
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,290
Funder: Université Paris Diderot
OpenAlex ID: W2685489489