Work

Analyzing disease-associated protein structures with visual analytics.

Year: 2013

Type: article

Abstract: Protein function is related to protein structure, and understanding disease-associated structural changes is critical both to understanding protein-mediated illness and to developing clinical therapies. We have developed a visual analytics tool called ContactWalker that uses molecular dynamics simulations to investigate the structural and physical differences between wild type and disease-associated protein structures. This tool has been used successfully to characterize the effects of the disease ataxia with vitamin E deficiency (AVED). We are now beginning to investigate mutations to other disease-associated proteins including the tumor suppressor protein p53.

Source: PubMed Central

Authors: Dennis Bromley, Valerie Daggett

Institution: University of Washington

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: U.S. National Library of Medicine

Award: University of Washington Biomedical Informatics and Data Science Research Training Program