Work

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Year: 2017

Type: article

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/j.bmcl.2017.07.011

Authors: Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase

Institutions: University of Tsukuba, International Institute for Integrative Sleep Medicine, University of Tsukuba, SHOWA Medical University

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: closed

Funders: Ministry of Education, Culture, Sports, Science and Technology, Toray Industries, Japan Society for the Promotion of Science

Awards: Development of novel molecular tool for controlling sleep/wake cycle and feeding behavior, Development of novel orexin ligand and its pharmacological activity, G5078116074, G6400963134, Elucidation of sleep/wakefulness regulation using forward genetic approach

OpenAlex ID: W2731627675

FWCI: 0.779

Cites: 20

Cited by: 15

Related to: 10